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pentobarbital will minimize the extent or impact of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Contraindicated (1)pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can reduce panobinostat stages by ~70% and cause